They reasoned that if they could control balance aerodynamically—using the forces air exerts on a wing—they could build an aircraft of any size and weight. A set of lifting surfaces, or wings. A method of balancing and controlling the aircraft. A means of propulsion. The LC—MS analysis of acid degraded sample was performed which showed that a peak at 8. The LC—MS analysis of base degraded sample showed a major degradation product at 8.
From mass data, the major acid and base degradation product was confirmed as 2-amino-4,5-dihydrobenzothiazol Fig. A Chromatogram of sunlight treated direct sunlight for 8 day pramipexole sample. The LC—MS analysis of photodegraded sample showed major degradation product at 6. Possible degradation product formed under photochemical degradation was confirmed as 4,5,6,7-tetrahydro propylamino benzothiazolyl carbamic acid Fig.
Inherent stability of helicopters
Pramipexole was found to be stable as negligible degradation was seen when subjected to dry and wet heat. The results of validation studies on the stability-indicating method developed for pramipexole involving methanol: The drug response was linear 0. The results of the repeatability and intermediate precision experiments are indexed in Table 1.
One factor at a time was changed to determine the effect. Insignificant differences in peak areas and less variability in retention time were observed Table 2.
The resolution of drug in the mixture of stressed sample was found to be similar when studies were performed on different chromatographic systems on different days, indicating that the method has sufficient ruggedness. The peaks obtained were sharp and had clear baseline separation. Commercially available pramipexole tablets from two different lots were analyzed using the proposed procedures and the results are indexed in Table 3.
As can be seen in Table 4 good recoveries of the drug in the range from An analytical method for determination of pramipexole in the presence of degradation products was developed.
Using various ICH recommended stress conditions, the behavior and intrinsic stability of pramipexole under various stress conditions was established and all degradation products were identified by the LC—MS method. The drug was well separated from the degradation products demonstrating the stability indicating capability of the method.
This study could be very useful for checking the quality of drug during stability studies. We would like to thank Dr. Hyderabad, Andhra Pradesh, India for providing gift sample of standard pramipexole. The authors would also like to thank Dr. Peer review under responsibility of Xi'an Jiaotong University.
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National Center for Biotechnology Information , U. Journal List J Pharm Anal v. Published online Aug Pawar , a Laxman D. Khatal , b Satish Y. Gabhe , a and Sunil R.
Spectacular Deals on Aeroplane Design and a Simple Explanation of Inherent Stability ()
Author information Article notes Copyright and License information Disclaimer. Received Apr 28; Accepted Jul Abstract Pramipexole belongs to a class of nonergot dopamine agonist recently approved for the treatment of early and advanced Parkinson's disease.
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Introduction Pramipexole is a new drug used in the therapy of Parkinson's disease. Open in a separate window. Materials and chemicals A pure drug sample of pramipexole Batch no. Instrumentation The LC method development, forced degradation studies and validation were done using Jasco Inc.
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Validation of the method Validation of the optimized LC method was done with respect to following parameters. Precision Precision was computed here by repeatability and intermediate precision. Hits and Misses of India's most awaited vehicle in Mahindra Alturas G4 India review: Train 18 Buzz Train 18 a super hit!
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